III-3. Prevention of skin photoaging by carotenoids
نویسندگان
چکیده
منابع مشابه
Skin Photoaging and the Role of Antioxidants in Its Prevention
Photoaging of the skin depends primarily on the degree of ultraviolet radiation (UVR) and on an amount of melanin in the skin (skin phototype). In addition to direct or indirect DNA damage, UVR activates cell surface receptors of keratinocytes and fibroblasts in the skin, which leads to a breakdown of collagen in the extracellular matrix and a shutdown of new collagen synthesis. It is hypothesi...
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Various natural carotenoids seem to be valuable for cancer prevention, and these carotenoids may be more suitable in combinational use, rather than in single use. In fact, we have proven that combinational use of natural carotenoids resulted in significant suppression of liver cancer. Patients of viral hepatitis with cirrhosis were administered with beta-cryptoxanthin-enriched Mandarin orange j...
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Carotenoids are known to be potent quenchers of singlet molecular oxygen [O(2) ((1)Δ(g))]. Solar light-induced photooxidative stress causes skin photoaging by accelerating the generation of reactive oxygen species via photodynamic actions in which O(2) ((1)Δ(g)) can be generated by energy transfer from excited sensitizers. Thus, dietary carotenoids seem to participate in the prevention of photo...
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The skin photoaging is characterized by keratinocyte hyperproliferation and degradation of collagen fibers, causing skin wrinkling and laxity and melanocyte proliferation that leads to pigmentation. UV is considered to be a major cause of such skin changes. It is well established that nuclear factor kappaB (NF-kappaB) is activated upon UV irradiation and induces various genes including interleu...
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The goal of this thesis study was to understand the role of TGF-3 in skin photoaging, especially in solar elastosis. Solar elastosis, the accumulation of elastotic material in the dermal extracellluar matrix, is a major hallmark of photoaging. However, the mechanisms by which UV radiation causes solar elastosis are poorly understood. TGF-3 is a multifunctional cytokine involved in the regulatio...
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ژورنال
عنوان ژورنال: NIPPON SUISAN GAKKAISHI
سال: 2011
ISSN: 1349-998X,0021-5392
DOI: 10.2331/suisan.77.266